Design, synthesis and bioactivity evaluations of 8-substituted-quinoline-2-carboxamide derivatives as novel histone deacetylase (HDAC) inhibitors
Yunpeng Zhao, Zefu Yao, Wandi Ren, Xinying Yang, Xuben Hou, Shengda Cao, Hao Fang
Topics & Concepts
VorinostatChemistryHistone deacetylaseQuinolineCarboxamideIC50PharmacologyHistone deacetylase inhibitorLead compoundHistoneBiochemistryIn vitroDNABiologyOrganic chemistryHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative DiseasesProtein Degradation and Inhibitors