New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of <i>Michelia champaca</i> : an <i>in vivo</i> and <i>in silico</i> approach
V. H. Pushpa, M. K. Jayanthi, H. R. Rashmi, Veeresh Kumar N. Shivamurthy, Shashank M. Patil, Prithvi S. Shirahatti, Ramith Ramu
Abstract
CONTEXT: L. (Magnoliaceae) has been known since ancient times for its rich medicinal properties. OBJECTIVE: studies. MATERIALS AND METHODS: studies included molecular docking against human potassium channel KCSA-FAB and human serotonin transporter, and ADME/T analysis. RESULTS: studies predicted doripenem to induce anxiolytic and antidepressant activity by inhibiting human potassium channel KCSA-FAB and human serotonin transporter proteins, respectively. CONCLUSIONS: EEMC is a rich source of bioactive compounds with strong antidepressant and anxiolytic properties.
Topics & Concepts
AnxiolyticDiazepamBehavioural despair testTail suspension testPharmacologyIn vivoPhytochemicalImipramineElevated plus mazeMedicineAntidepressantTraditional medicineChemistryBiologyInternal medicineAnxietyHippocampusPathologyPsychiatryReceptorBiotechnologyAlternative medicineNeuropeptides and Animal PhysiologyTraditional and Medicinal Uses of AnnonaceaeAlkaloids: synthesis and pharmacology