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Design, synthesis, evaluation, and SAR of 4-phenylindoline derivatives, a novel class of small-molecule inhibitors of the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) interaction

Yang Yang, Ke Wang, Hao Chen, Zhiqiang Feng

2020European Journal of Medicinal Chemistry42 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryJurkat cellsSmall moleculeStereochemistryIC50Structure–activity relationshipDimerDocking (animal)Ligand (biochemistry)In vitroT cellBiochemistryReceptorImmune systemNursingBiologyMedicineOrganic chemistryImmunologyCancer Immunotherapy and BiomarkersCAR-T cell therapy researchPeptidase Inhibition and Analysis
Design, synthesis, evaluation, and SAR of 4-phenylindoline derivatives, a novel class of small-molecule inhibitors of the programmed cell death-1/ programmed cell death-ligand 1 (PD-1/PD-L1) interaction | Litcius