CD44 in Bladder Cancer
Jason E. Duex, Dan Theodorescu
Abstract
The glycoprotein CD44, with its many isoforms and variations in carbohydrate patterning, participates in a diverse set of cellular functions. This fact leads to the protein playing a role in many normal and pathologic cellular processes including a role in cancer progression and metastasis. These same facts make CD44 a strong therapeutic target in many cancer types, including bladder cancer.
Topics & Concepts
CD44MetastasisCancerBladder cancerCancer researchGene isoformCancer cellCancer metastasisMedicineBiologyBioinformaticsComputational biologyInternal medicineCellBiochemistryGeneGlycosylation and Glycoproteins ResearchProteoglycans and glycosaminoglycans researchCarbohydrate Chemistry and Synthesis