Counteranions in the Stimulation Solution Alter the Dynamics of Exocytosis Consistent with the Hofmeister Series
Xiulan He, Andrew G. Ewing
Abstract
). Based on ion specificity, an adsorption-repulsion mechanism, we suggest that the exocytotic Hofmeister series effect originates from a looser swelling lipid bilayer structure due to the adsorption and electrostatic repulsion of chaotropes on the hydrophobic portion of the membrane. Our results provide a chemical link between the Hofmeister series and the cellular process of neurotransmitter release via exocytosis and provide a better physical framework to understand this important phenomenon.
Topics & Concepts
ChemistryHofmeister seriesExocytosisSeries (stratigraphy)Dynamics (music)StimulationIonBiochemistryNeuroscienceMembraneOrganic chemistryAcousticsPhysicsPaleontologyBiologySpectroscopy and Quantum Chemical StudiesPhotoreceptor and optogenetics researchLipid Membrane Structure and Behavior