A novel pyrazolo [3,4-d] pyrimidine, KKC080106, activates the Nrf2 pathway and protects nigral dopaminergic neurons
Ji Ae Lee, Hye Ri Kim, Hyo Jin Son, Nari Shin, Se Hee Han, Chan Seong Cheong, Dong Jin Kim, Onyou Hwang
Topics & Concepts
NeuroprotectionPharmacologyDopaminergicChemistryNitric oxide synthaseMAPK/ERK pathwayKinaseNitric oxideBiochemistryNeurodegenerationDopamineEnzymeBiologyMedicineInternal medicineEndocrinologyOrganic chemistryDiseaseGenomics, phytochemicals, and oxidative stressTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms