Strain-release trifluoromethoxylation and pentafluorosulfanoxylation of [1.1.0]bicyclobutanes: expanded access to fluorinated cyclobutane hybrid bioisosteres
Yannick Kraemer, Alexander M. Stephens, Jón Atiba Buldt, Aurelius Young, Connor P. McLoughlin, James C. Fettinger, Lauren M. Holder, Cody Ross Pitts
Abstract
Methods for formal bromo-trifluoromethoxylation and bromo-pentafluorosulfanoxylation of [1.1.0]bicyclobutanes using AgOCF 3 or AgOSF 5 and 1,3-dibromo-5,5-dimethylhydantoin are disclosed.
Topics & Concepts
CyclobutaneStrain (injury)ChemistryStereochemistryBiologyRing (chemistry)Organic chemistryAnatomyFluorine in Organic ChemistryChemical Synthesis and ReactionsOrganic Chemistry Cycloaddition Reactions