Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy
Ziyi Liang, Yuqing Wang, Honghua Zhang, Jiedan Deng, Lei Fang, Junfang Li, Tao Shi, Shuzhi Wang, Ranhui Li, Zhen Wang
Topics & Concepts
EvodiamineChemistryApoptosisIn vivoIC50Cell cycleDerivatizationPharmacologyNatural productCell growthCancer cellCancerIn vitroToxicityCancer researchStereochemistryBiochemistryHigh-performance liquid chromatographyInternal medicineMedicineBiologyChromatographyOrganic chemistryBiotechnologyQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms