A new clade of styrene monooxygenases for (<i>R</i>)-selective epoxidation
Xiao Hu, Shuang Dong, Yan Liu, Xiao-Qiong Pei, Hui Lin, Zhong‐Liu Wu
Abstract
Styrene monooxygenases (SMOs) are excellent enzymes for the production of (<italic>S</italic>)-enantiopure epoxides, but so far, only one (<italic>R</italic>)-selective SMO has been identified with a narrow substrate spectrum.
Topics & Concepts
Enantiopure drugMonooxygenaseStyreneSubstrate (aquarium)Methane monooxygenaseCatalysisSubstrate specificityCladeChemistryBiocatalysisEnzymeStereochemistryBiologyOrganic chemistryReaction mechanismGeneBiochemistryCytochrome P450Enantioselective synthesisPhylogeneticsEcologyPolymerCopolymerEnzyme Catalysis and ImmobilizationMetal-Catalyzed Oxygenation MechanismsMicrobial Metabolic Engineering and Bioproduction