In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy
Biyu Hou, Peng Ma, Xinyu Yang, Xiaoyue Zhao, Li Zhang, Yuerong Zhao, Ping He, Li Zhang, Guanhua Du, Guifen Qiang
Topics & Concepts
Diabetic nephropathyPuerarinIn vivoPharmacologyNephropathyViability assayExtracellular matrixMesangial cellWestern blotKidneyChemistryMedicineDiabetes mellitusIn vitroBiologyInternal medicineEndocrinologyBiochemistryPathologyGeneBiotechnologyAlternative medicineFerroptosis and cancer prognosisPhytoestrogen effects and researchChronic Kidney Disease and Diabetes