PxdA interacts with the DipA phosphatase to regulate peroxisome hitchhiking on early endosomes
John Salogiannis, Jenna R. Christensen, Livia D. Songster, Adriana Aguilar-Maldonado, Nandini Shukla, Samara L. Reck‐Peterson
Abstract
alleles, including a point mutation (R2044P) that disrupts PxdA's ability to associate with EEs and reduces peroxisome movement. We also identify a novel regulator of peroxisome hitchhiking, the phosphatase DipA. DipA colocalizes with EEs and its association with EEs relies on PxdA. Together, our data suggest that PxdA and the DipA phosphatase are specific regulators of peroxisome hitchhiking on EEs.
Topics & Concepts
EndosomeBiologyCell biologyPeroxisomePhosphataseReceptorBiochemistryPhosphorylationFungal and yeast genetics researchMitochondrial Function and PathologyCellular transport and secretion