The <i>β</i> -TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation <i>In Vivo</i>
Ayumi Kuga, Kouhei Tsuchida, Harit Panda, Makoto Horiuchi, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Mikiko Suzuki, Masayuki Yamamoto
Abstract
mutation caused severe hyperplasia and hyperkeratosis in the esophageal epithelium but did not cause abnormalities in the other tissues/organs examined. These results indicate that the β-TrCP-mediated pathway cooperates with the Keap1-mediated pathway to regulate Nrf2 activity, which is apparent when the Keap1-mediated pathway is profoundly suppressed.
Topics & Concepts
KEAP1BiologyMutantSerineIn vivoMutationMolecular biologyCell biologyPhosphorylationCancer researchGeneBiochemistryGeneticsTranscription factorGenomics, phytochemicals, and oxidative stressChildhood Cancer Survivors' Quality of LifeIL-33, ST2, and ILC Pathways