Overestimation of Stroke Risk in Rheumatic Mitral Stenosis and the Implications for Oral Anticoagulation
Ganesan Karthikeyan, Stuart J. Connolly, Salim Yusuf
Abstract
heumatic heart disease (RHD) is an important cause of stroke in low-and middle-income countries. About 80% of the strokes in patients with RHD occur in patients with mitral stenosis (MS) and atrial fibrillation (AF). The pathophysiology and risk markers of stroke in patients with MS and AF are well recognized, but because of a paucity of good quality data, the optimal anticoagulation strategy for stroke prevention in these patients is not known.
Topics & Concepts
MedicineStroke (engine)Atrial fibrillationStenosisPopulationInternal medicineCardiologyMechanical engineeringEnvironmental healthEngineeringAtrial Fibrillation Management and OutcomesAcute Myocardial Infarction ResearchCardiac Valve Diseases and Treatments