The significance of chirality in contemporary drug discovery-a mini review
Narmatha Senkuttuvan, Boopathi Komarasamy, Rajavenkatesh Krishnamoorthy, Shuvajyoti Sarkar, Sivasankaran Dhanasekaran, Parthiban Anaikutti
Abstract
Advancements in asymmetric synthesis in recent years have led to considerable interest in the development of single enantiomers of chiral drug molecules for medicinal chemistry settings. In this review, we want to compile examples of chiral medicines approved by the FDA in the years 2022 and 2023 with an emphasis on their synthesis along with information on chiral induction as well as enantiomeric excess.
Topics & Concepts
Chirality (physics)EnantiomerCombinatorial chemistryDrugNanotechnologyChemistryPharmacologyMedicineMaterials scienceStereochemistryPhysicsNuclear physicsQuarkChiral symmetry breakingNambu–Jona-Lasinio modelAnalytical Chemistry and ChromatographyPharmacogenetics and Drug MetabolismPharmacological Effects of Natural Compounds