Hawthorn flavonoid ameliorates cognitive deficit in mice with Alzheimer's disease by increasing the levels of <i>Bifidobacteriales</i> in gut microbiota and docosapentaenoic acid in serum metabolites
Jinxuan Zhang, Junyu Hao, Ran Liu, Tao Wu, Rui Liu, Wenjie Sui, Min Zhang
Abstract
, as well as increasing the levels of docosapentaenoic acid (DPA), sphingolipid (SM), and phosphatidylcholine (PC). Notably, a positive correlation between DPA and Bifidobacterium was observed for the first time. Therefore, HF may serve as a promising dietary supplement for improving the symptoms of Alzheimer's disease.
Topics & Concepts
Docosapentaenoic acidFlavonoidGut floraDiseaseChemistryBiologyBiochemistryMedicineInternal medicineAntioxidantDocosahexaenoic acidFatty acidPolyunsaturated fatty acidBotanical Studies and ApplicationsMedicinal Plants and Bioactive CompoundsMicrobial Metabolism and Applications