Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets
Roslyn M. Ray, Kevin V. Morris
Abstract
This review aims to highlight the role of long non-coding RNAs in mediating human immunodeficiency virus (HIV-1) viral replication, latency, disease susceptibility and progression. In particular, we focus on identifying possible lncRNA targets and their purported mechanisms of action for future drug design or gene therapeutics.
Topics & Concepts
Human immunodeficiency virus (HIV)Computational biologyBiologyCoding (social sciences)Identification (biology)Long non-coding RNAViral replicationLentivirusGeneLatency (audio)VirusRNAVirologyViral diseaseGeneticsComputer scienceStatisticsBotanyTelecommunicationsMathematicsCancer-related molecular mechanisms researchRNA modifications and cancerRNA Research and Splicing