Liposomes loaded with polyphenol-rich grape pomace extracts protect from neurodegeneration in a rotenone-based<i>in vitro</i>model of Parkinson's disease
Attilio Marino, Matteo Battaglini, Andrea Desii, Chiara Lavarello, Giada Graziana Genchi, Andrea Petretto, Gianni Ciofani
Abstract
model of PD, where it completely rescued the ROS levels, prevented the aggregation of α-synuclein fibrils, and restored cell viability, paving the way for preclinical translation of the approach.
Topics & Concepts
RotenonePomaceNeurodegenerationLiposomePolyphenolIn vitroChemistryParkinson's diseaseTraditional medicineBiochemistryFood sciencePharmacologyBiologyDiseaseAntioxidantMedicineMitochondrionPathologyParkinson's Disease Mechanisms and TreatmentsSirtuins and Resveratrol in MedicineNerve injury and regeneration