Total Synthesis of Natural Products Using Intramolecular Nozaki–Hiyama–Takai–Kishi Reactions
Ken‐ichi Takao, Akihiro Ogura, Keisuke Yoshida, Siro Simizu
Abstract
In this Account, we describe our studies on the total synthesis of several natural products using intramolecular Nozaki–Hiyama–Takai–Kishi (NHTK) reactions. In each synthesis, an NHTK reaction is used to efficiently construct a medium-sized ring. These examples demonstrate the utility of the intramolecular NHTK reaction in natural product synthesis. 1 Introduction 2 Total Synthesis of (+)-Pestalotiopsin A 3 Total Synthesis of (+)-Cytosporolide A 4 Total Synthesis of (+)-Vibsanin A 5 Total Syntheses of (+)-Aquatolide and Related Humulanolides 6 Conclusion
Topics & Concepts
Total synthesisIntramolecular forceChemistryNatural productRing (chemistry)StereochemistryOrganic chemistrySynthetic Organic Chemistry MethodsTraditional and Medicinal Uses of AnnonaceaePlant-derived Lignans Synthesis and Bioactivity