In Vitro Antifungal Susceptibility Profile of Miltefosine against a Collection of Azole and Echinocandins Resistant Fusarium Strains
Mohsen Nosratabadi, Javad Akhtari, Leila Faeli, Iman Haghani, Seyed Reza Âghili, Tahereh Shokohi, Mohammad Taghi Hedayati, Hossein Zarrinfar, Rasoul Mohammadi, Mohammad Javad Najafzadeh, Sadegh Khodavaisy, Ahmed Al‐Harrasi, M. Javan‐Nikkhah, Reza Kachuei, Maryam Salimi, Azam Fattahi, Hamid Badali, Abdullah M. S. Al‐Hatmi, Mahdi Abastabar
Abstract
Fusarium species are filamentous fungi that cause a variety of infections in humans. Because they are commonly resistant to many antifungal drugs currently available in clinical settings, research into alternative targets in fungal cells and therapeutic approaches is required. The antifungal activity of miltefosine and four comparators, amphotericin B, voriconazole, itraconazole, and caspofungin, were tested in vitro against a collection of susceptible and resistant clinical (n = 68) and environmental (n = 42) Fusarium isolates. Amphotericin B (0.8 μg/mL) had the lowest geometric mean (GM) MICs/MECs values followed by miltefosine (1.44 μg/mL), voriconazole (2.15 μg/mL), caspofungin (7.23 μg/mL), and itraconazole (14.19 μg/mL). Miltefosine was the most effective agent against Fusarium isolates after amphotericin B indicating that miltefosine has the potential to be studied as a novel treatment for Fusarium infections.