The cAMP responsive element modulator (CREM) is a regulator of CD4<sup>+</sup> T cell function
Sudheendra Hebbar Subramanyam, Klaus Tenbrock
Abstract
Abstract The cAMP responsive element modulator (CREM) is a transcriptional regulator of different effector cytokines in CD4 + T cells including IL-2, IL-17, IL-21 but also IL-4 and IL-13 and thus an important determinant of central T helper cell functions. Our review gives an overview over the regulation of CREM in T cells and the pleiotropic effects of CREM on CD4 + T cells in health and autoimmune diseases with a particular focus on systemic lupus erythematosus.
Topics & Concepts
RegulatorEffectorCell biologyFunction (biology)Transcriptional regulationImmunologyBiologyChemistryTranscription factorGeneBiochemistryImmune Cell Function and InteractionCytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology