Synthesis of Sulfilimines via Aryne and Cyclohexyne Intermediates
Xianda Wu, Minghong Chen, Fu‐Sheng He, Jie Wu
Abstract
An efficient and metal-free approach for the synthesis of sulfilimines from sulfenamides with aryne and cyclohexyne precursors has been developed. The reaction proceeds through unusual S-C bond formation, which offers a novel and practical entry to access a wide range of sulfilimines in moderate to good yields with excellent chemoselectivity. Moreover, this protocol is amenable to gram-scale synthesis and is applicable to the transformation of the products into useful sulfoximines.
Topics & Concepts
AryneChemistryChemoselectivityCombinatorial chemistryReaction conditionsTransformation (genetics)Organic chemistryCatalysisGeneBiochemistrySynthesis and Catalytic ReactionsCyclization and Aryne ChemistrySynthesis and Biological Evaluation