Discovery of (quinazolin-6-yl)benzamide derivatives containing a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety as potent reversal agents against P-glycoprotein-mediated multidrug resistance
Wen-han Xue, Kai-li Liu, Tingjian Zhang, Gang Dong, Jiahui Wang, Jing Wang, Shuai Guo, Jie Hu, Qingyu Zhang, Xinyang Li, Fan‐hao Meng
Topics & Concepts
ChemistryLapatinibP-glycoproteinMultiple drug resistanceBenzamidePharmacologyQuinazolinoneQuinazolineRhodamine 123Lead compoundEGFR inhibitorsStereochemistryIn vitroBiochemistryCancerEpidermal growth factor receptorReceptorTrastuzumabBreast cancerInternal medicineMedicineAntibioticsCancer therapeutics and mechanismsDrug Transport and Resistance MechanismsLung Cancer Treatments and Mutations