Highly Sensitive Protein Detection by Asymmetric Mach–Zehnder Interferometry for Biosensing Applications
Melissa J. Goodwin, G.A.J. Besselink, Floris Falke, Arnoud S. Everhardt, Jeroen J. L. M. Cornelissen, Jurriaan Huskens
Abstract
). These values were then used to evaluate that 45% of the measured streptavidin mass in the QCM-D came from hydrodynamically coupled water. Importantly, the signal-to-noise ratio of the aMZI was found to be 200 times higher than that of the QCM-D. These results indicate the potential of the aMZI platform for highly sensitive and accurate biosensing applications.
Topics & Concepts
Mach–Zehnder interferometerInterferometryBiosensorProtein detectionNanotechnologyPhysicsOpticsMaterials sciencePhotonic and Optical DevicesMechanical and Optical ResonatorsAnalytical Chemistry and Sensors