Synergistic Quinolone Sensitization by Targeting the <i>recA</i> SOS Response Gene and Oxidative Stress
Sara Díaz-Díaz, Esther Recacha, Jesús Machuca, A García-Duque, Fernando Docobo-Pérez, Jesús Blázquez, Álvaro Pascual, José Manuel Rodríguez-Martínez
Abstract
Suppression of the recA SOS response gene and reactive oxygen species (ROS) overproduction have been shown, separately, to enhance fluoroquinolone activity and lethality. Their putative synergistic impact as a strategy to potentiate the efficacy of bactericidal antimicrobial agents such as fluoroquinolones is unknown.
Topics & Concepts
Oxidative stressQuinoloneSensitizationSOS responseGenePharmacologyMicrobiologyBiologyChemistryMedicineAntibioticsGeneticsImmunologyEscherichia coliBiochemistryAntibiotics Pharmacokinetics and EfficacyBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria