Mucosal microRNAs relate to age and severity of disease in ulcerative colitis
Mikkel Malham, Jaslin James, Christian Jakobsen, Estrid Hoegdall, Kim Holmstroem, Vibeke Wewer, Boye Schnack Nielsen, Lene Riis
Abstract
hybridization followed by image analysis, the expression level estimates of miR-21 and miR-126 correlated with histological assessed disease severity. In conclusion, we found that the expression of miRNAs depends on the age of the patient and/or the severity of the disease, suggesting that miRNAs may contribute to the regulation of inflammation in UC and could be useful biomarkers in the surveillance of disease severity.
Topics & Concepts
microRNADiseaseUlcerative colitisMedicineInternal medicineReal-time polymerase chain reactionYoung adultPathologyPhenotypeInflammatory bowel diseaseInflammationGastroenterologyOncologyGeneBiologyGeneticsMicroRNA in disease regulationExtracellular vesicles in diseaseCircular RNAs in diseases