Zwitterionic Block Copolymer Prodrug Micelles for pH Responsive Drug Delivery and Hypoxia-Specific Chemotherapy
Jianyang Zhao, Yi‐Yang Peng, Diana Diaz‐Dussan, John White, Wei Duan, Lingxue Kong, Ravin Narain, Xiaojuan Hao
Abstract
cytotoxicity assay. The pH-responsiveness and hypoxia-specific cytotoxicity confer BCP-TPZ micelles a great potential to achieve precise delivery of TPZD and thus enhance the therapeutic effect toward tumor-hypoxia.
Topics & Concepts
ProdrugCytotoxicityChemistryTirapazamineDrug deliveryMicelleNanocarriersEthylene glycolConjugateCombinatorial chemistryPhosphorylcholineIn vitroOrganic chemistryBiochemistryAqueous solutionMathematical analysisMathematicsNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryCancer, Hypoxia, and Metabolism