<i>In Vitro</i> Antibacterial Activity of Cefiderocol against Multidrug-Resistant Acinetobacter baumannii
Jacinda C. Abdul‐Mutakabbir, Logan Nguyen, Philip Maassen, Kyle Stamper, Razieh Kebriaei, Keith S. Kaye, Mariana Castanheira, Michael J. Rybak
Abstract
Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC MIC values (87% of MICs ≤ 4mg/liter) than the comparator Gram-negative agents. Six isolates, with elevated CFDC MICs (16 to 32 mg/liter) were selected for further experiments. Time-kill analyses presented with synergistic activity and beta-lactamase inhibitors increased CFDC susceptibility in each of the isolates.