Performance of the Sofia SARS-CoV-2 Rapid Antigen Test in Symptomatic and Asymptomatic Pediatric Patients
Megan Culler Freeman, Tanner J. Freeman, Jennifer Iagnemma, Jayne Rasmussen, Kelly Heidenreich, Alan Wells, Alejandro Hoberman, Stephanie Mitchell
Abstract
The sensitivity and specificity of SARS-CoV-2 antigen tests have not been widely assessed in children. We evaluated children presenting to outpatient care with Quidel Sofia SARS-CoV-2 antigen test (Sofia-Ag-RDT) compared against Cepheid Xpert Xpress SARS-CoV-2/Flu/RSV reverse transcriptase-polymerase chain reaction test from November 2020 to April 2021. Sofia-Ag-RDT had the highest sensitivity in symptomatic (82%; 95% confidence interval, 68%-91%) children.
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)AsymptomaticCoronavirus disease 2019 (COVID-19)Virology2019-20 coronavirus outbreakAntigenImmunologyPediatricsInternal medicineOutbreakDiseaseInfectious disease (medical specialty)SARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 ResearchRespiratory viral infections research