Advances in capillary electrophoresis mass spectrometry for metabolomics
Tomoyoshi Soga
Abstract
Capillary electrophoresis mass spectrometry (CE-MS) is now regarded as a powerful tool for the comprehensive analysis of low-molecular-weight charged metabolites. Over the past decades, several CE-MS methods have been established and made significant contributions to metabolomics research in various areas. This review describes the general strategies and principles of the CE-MS-based metabolomics analyses, including sample preparation, CE separation modes, interfacing techniques, and mass spectrometers. Furthermore, new techniques to increase throughput ability in CE-MS for metabolomics are highlighted. Finally, general conclusions and perspectives are provided.
Topics & Concepts
MetabolomicsCapillary electrophoresisCapillary electrophoresis–mass spectrometryMass spectrometryInterfacingChromatographyChemistryComputer scienceElectrospray ionizationComputer hardwareMetabolomics and Mass Spectrometry StudiesAdvanced Chemical Sensor TechnologiesAnalytical Chemistry and Chromatography