Chiroptical sensing of amino acids, amines, amino alcohols, alcohols and terpenes with π-extended acyclic cucurbiturils
Diandra S. Hassan, Zeus A. De los Santos, Kimberly G. Brady, Steven Murkli, Lyle Isaacs, Christian Wolf
Abstract
The efficiency and scope of two acyclic π-wall extended cucurbiturils, M2 and M3, exhibiting rapidly interconverting helical conformers for chiroptical sensing of amines, amino acids, alcohols, and terpenes at micromolar concentrations in water is evaluated. The formation of 1 : 1 host-guest complexes results in spontaneous induction of circular dichroism signals that can be used for accurate determination of the absolute configuration and enantiomeric composition of the analyte based on a simple mix-and-measure protocol.
Topics & Concepts
CucurbiturilChemistryTerpeneAmino acidOrganic chemistryCombinatorial chemistryMoleculeBiochemistrySupramolecular chemistrySupramolecular Chemistry and ComplexesMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials