Age-dependent remodeling of gut microbiome and host serum metabolome in mice
Chia‐Shan Wu, Sai Deepak Venkata Muthyala, Cory Klemashevich, A. Ufondu, Rani Menon, Zheng Chen, Sridevi Devaraj, Arul Jayaraman, Yuxiang Sun
Abstract
, which may lead to altered mucus structure more susceptible to bacteria penetration and ultimately increased intestinal inflammation. Metabolomic profiling of polar serum metabolites at fed state in 3, 12, 18 and 28M mice revealed age-associated changes in metabolic cascades involved in tryptophan, purine, amino acids, and nicotinamide metabolism. Correlation analyses showed that nicotinamide decreased with age, while allantoin and guanosine, metabolites in purine metabolism, increased with age. Notably, tryptophan and its microbially derived compounds indole and indole-3-lactic acid significantly decreased with age, while kynurenine increased with age. Together, these results suggest a significant interplay between bacterial and host metabolism, and gut dysbiosis and altered microbial metabolism contribute to aging.