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Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model

Johannes Gebert, Ozkan Gelincik, Mine Oezcan-Wahlbrink, Jason D. Marshall, Alejandro Hernandez‐Sanchez, Katharina Urban, Mark D. Long, Eduardo Cortes, Elena Tosti, Eva‐Maria Katzenmaier, Yurong Song, Ali Elsaadi, Nan Deng, Eduardo Vilar, Vera Fuchs, Nina Nelius, Yan P. Yuan, Aysel Ahadova, Shizuko Sei, Robert H. Shoemaker, Asad Umar, Lei Wei, Song Liu, Peer Bork, Winfried Edelmann, Magnus von Knebel Doeberitz, Steven M. Lipkin, Matthias Kloor

2021Gastroenterology115 citationsDOIOpen Access PDF

Topics & Concepts

Frameshift mutationMicrosatellite instabilityLynch syndromeDNA mismatch repairColorectal cancerCancerCancer researchGermline mutationImmunogenicityBiologyMedicineImmunologyMutationGeneticsGeneImmune systemMicrosatelliteAlleleGenetic factors in colorectal cancerCancer Immunotherapy and BiomarkersImmunodeficiency and Autoimmune Disorders