Divergent oriented synthesis (DOS) of aza-heterocyclic amides through palladium-catalyzed ketenimination of 2-iodo-<i>N</i>-(propa-1,2-dien-1-yl)anilines
Xiaoyan Chen, Guanyinsheng Qiu, Renzhi Liu, Dianpeng Chen, Zhiyuan Chen
Abstract
A palladium-catalyzed tandem reaction of <italic>N</italic>-(2-iodophenyl)-4-methyl-<italic>N</italic>-(propa-1,2-dien-1-yl)benzenesulfonamide with isocyanide is described to divergently produce aza-heterocyclic amides.
Topics & Concepts
ChemistryPalladiumCatalysisIsocyanideMedicinal chemistryTandemCombinatorial chemistryStereochemistryOrganic chemistryMaterials scienceComposite materialCatalytic C–H Functionalization MethodsChemical Synthesis and AnalysisSynthesis and Biological Evaluation