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Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors

Lamya H. Al-Wahaibi, Ahmed M. Gouda, Ola F. Abou‐Ghadir, Ola I. A. Salem, Asmaa T. Ali, Hatem S. Farghaly, Mostafa Abdelrahman, Laurent Trembleau, Hajjaj H.M. Abdu-Allah, Bahaa G. M. Youssif

2020Bioorganic Chemistry76 citationsDOI

Topics & Concepts

ChemistryErlotinibEGFR inhibitorsIndole testKinaseIC50Docking (animal)Cell cycle checkpointCell cycleApoptosisVemurafenibCell culturePharmacologyEpidermal growth factor receptorCell growthStereochemistryBiochemistryIn vitroCancer researchReceptorMelanomaBiologyMedicineNursingMetastatic melanomaGeneticsMelanoma and MAPK PathwaysCancer therapeutics and mechanismsSynthesis and biological activity
Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors | Litcius