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Innovation in Providing Equitable Pre‐exposure Prophylaxis Services in the United States: Expanding Access in Nontraditional Settings

Joanne E. Mantell, Laurie J. Bauman, Stephen Bonett, Susan Buchbinder, Susie Hoffman, Erik D. Storholm, Katryna McCoy, Christine Tagliaferri Rael, Ethan Cowan, Tatiana Gonzalez-Argoti, Hussein Safa, Hyman Scott, Kimberly Ling Murtaugh, Natalie Wilson, Albert Liu

2025JAIDS Journal of Acquired Immune Deficiency Syndromes12 citationsDOIOpen Access PDF

Abstract

BACKGROUND: Pre-exposure prophylaxis (PrEP) usage has slowly increased in the United States, but significant disparities persist across race, ethnicity, sex, gender, age, and geography. Determinants of PrEP inequities include stigma and medical mistrust, lack of patient-centered services, lack of access to clinical care, and organizational resistance to change-within a health care system that neglects these barriers. METHODS: We describe 5 implementation strategies to providing PrEP in nontraditional settings to underserved populations, using an equity-based approach to address key structural determinants. The alternative settings used in these Ending the HIV Epidemic projects (community-based organizations, telePrEP, mobile clinics, pharmacies, emergency departments) were chosen for the setting characteristics and their serving structurally underserved populations. RESULTS: Community-based organizations have earned trust within communities and can serve as hubs for comprehensive sexual health services, including PrEP. Telehealth, which expanded significantly because of COVID-19, can help overcome transportation and scheduling barriers to PrEP access. Mobile clinics can also broaden PrEP delivery by bringing tailored services directly to communities, often providing shorter wait times and extended hours. Pharmacists can prescribe PrEP in certain states through legislation or collaborative practice agreements, offering a convenient, community-based option. Emergency departments provide an alternative site for PrEP delivery, with the potential to reach individuals not currently engaged in regular care. CONCLUSION: These alternative PrEP approaches can expand options for accessing PrEP and alleviate key barriers to care in traditional settings, although they may not eliminate all inequities. Offering more choices increases the likelihood that a broader population will be reached, thereby enhancing overall access to PrEP.

Topics & Concepts

Equity (law)LegislationMedicineHealth careTelehealthHealth equityPharmacyPopulationBusinessPublic relationsBest practiceFamily medicineNursingPolitical scienceTelemedicineEnvironmental healthPublic healthLawHIV/AIDS Research and InterventionsInfection Control in HealthcareSex work and related issues
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