<i>N</i>,<i>O</i>-Benzamide difluoroboron complexes as near-infrared probes for the detection of β-amyloid and tau fibrils
Yimin Chen, Chang Yuan, Tianxin Xie, Yuying Li, Bin Dai, Kaixiang Zhou, Yi Liang, Jiapei Dai, Hongwei Tan, Mengchao Cui
Abstract
In this study, a series of organo difluoroboron probes with a BF2 benzamide moiety was designed, prepared and evaluated. Among them, 2c displayed the best optical and biological properties, and may be used as a useful near-infrared fluorescent probe for the detection of Aβ plaques and neurofibrillary tangles in AD.
Topics & Concepts
BenzamideChemistryAmyloid fibrilInfraredFibrilAmyloid (mycology)Amyloid βPolymer chemistryPhotochemistryStereochemistryBiochemistryOpticsInorganic chemistryPhysicsMedicinePathologyDiseaseLuminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionAlzheimer's disease research and treatments