A copper complex that combats triple negative breast cancer by restraining angiogenesis
Huixian Zheng, Chaoyi Hu, Yun‐Yun Quan, Xiaoxia Ye, Xiangchao Shi, Zijian Guo, Xiaoyong Wang
Abstract
The copper complex CPT8 exhibits potent antiproliferative and antiangiogenic activities to suppress breast cancer; it induces mitophagy in BC cells and inhibits vascularization in tumor microenvironments by modulating a series of functional proteins.
Topics & Concepts
Triple-negative breast cancerMMP2AngiogenesisCancer researchVascular endothelial growth factorDownregulation and upregulationVasculogenic mimicryMetastasisChemistryUmbilical veinMMP9CD34Matrix metalloproteinaseBreast cancerCancerBiologyMedicineCell biologyInternal medicineStem cellIn vitroBiochemistryVEGF receptorsGeneFerroptosis and cancer prognosisRNA modifications and cancerHistone Deacetylase Inhibitors Research