Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
Paolo Vignali, Kristin DePeaux, McLane J. Watson, Chenxian Ye, B. Rhodes Ford, Konstantinos Lontos, Nicole K. McGaa, Nicole E. Scharping, Ashley V. Menk, Simon C. Robson, Amanda C. Poholek, Dayana B. Rivadeneira, Greg M. Delgoffe
Topics & Concepts
ImmunotherapyCytotoxic T cellTumor microenvironmentCD8Cancer researchFOXP3Cancer immunotherapyImmune systemBiologyT cellImmunologyHypoxia (environmental)PopulationCell biologyChemistryMedicineIn vitroBiochemistryOrganic chemistryEnvironmental healthOxygenImmune Cell Function and InteractionCAR-T cell therapy researchCancer Immunotherapy and Biomarkers