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Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors

Jae Eun Jung, Yunseong Jang, Hee Jin Jeong, Sung Joon Kim, Ki Chul Park, Do Hee Oh, Ah-Ran Yu, Chan Sun Park, Seo‐Jung Han

2022Bioorganic & Medicinal Chemistry Letters12 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryMicrosomePhosphodiesteraseStimulator of interferon genesStereochemistryPyrophosphataseIn vitroBiochemistryEnzymeCytosolinterferon and immune responsesCytokine Signaling Pathways and InteractionsResearch on Leishmaniasis Studies
Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors | Litcius