Disentangling the Puzzling Regiochemistry of Thiol Addition to <i>o</i>-Quinones
Maria Laura Alfieri, Alice Cariola, Lucia Panzella, Alessandra Napolitano, Marco d’Ischia, Luca Valgimigli, Orlando Crescenzi
Abstract
-quinone conjugation and stimulate further work aimed at assessing the impact of the free radical processes in biologically relevant thiol-quinone interactions.
Topics & Concepts
RegioselectivityQuinoneChemistryThiolNucleophileCysteineRadicalGlutathioneBenzoquinoneCombinatorial chemistryStereochemistryOrganic chemistryCatalysisEnzymeFree Radicals and AntioxidantsOrganic Chemistry Cycloaddition ReactionsBioactive Compounds and Antitumor Agents