Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of <i>ENO1</i>-Deleted Cancers
Victoria C. Yan, Cong-Dat Pham, Elliot Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, M. K. Washington, Sudhir Raghavan, Barbara Czakó, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Müller
Abstract
. The activity of select prodrugs was also probed using the NCI-60 cell line screen, supporting its use to examine the relationship between prodrugs and cell line-dependent bioactivation.
Topics & Concepts
ProdrugChemistryEnolasePhosphonateEnzymeCell cultureBiochemistryGliomaIsozymePharmacologyCancer researchBiologyImmunohistochemistryImmunologyGeneticsCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMitochondrial Function and Pathology