Extension of <i>O</i> -Linked Mannosylation in the Golgi Apparatus Is Critical for Cell Wall Integrity Signaling and Interaction with Host Cells in Cryptococcus neoformans Pathogenesis
Eun Jung Thak, Ye Ji Son, Dong-Jik Lee, Hyun‐Ah Kim, Jung Ho Kim, Su‐Bin Lee, Yu-Byeong Jang, Yong‐Sun Bahn, Connie B. Nichols, J. Andrew Alspaugh, Hyun Ah Kang
Abstract
Cryptococcus neoformans assembles two types of O -linked glycans on its surface proteins, the more abundant major O -glycans that do not contain xylose residues and minor O -glycans containing xylose. Here, we demonstrate the role of the Cap6 α1,3-mannosyltransferase in the synthesis of minor O -glycans.
Topics & Concepts
Cryptococcus neoformansBiologyMannoseCell biologyGlycanGolgi apparatusVirulenceMicrobiologyBiochemistryGeneGlycoproteinEndoplasmic reticulumFungal Infections and StudiesAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies