Role of IL-6 and IL-6 targeted therapy in systemic lupus erythematosus
Desh Nepal, David Gazeley
Abstract
Interleukin-6 (IL-6) is one of the cytokines implicated in murine and human SLE. Only a few small studies have investigated IL-6 inhibition in human SLE. Currently, there are no studies registered in clinicaltrials.gov to assess the IL-6 targeted therapy in SLE, yet its role in the future remains to be defined. This narrative review analyses these and potential areas of future studies with IL-6 targeted therapy in SLE.
Topics & Concepts
MedicineImmunologyNarrative reviewInterleukinTargeted therapyInterleukin 17Lupus erythematosusSystemic lupus erythematosusCytokineInternal medicineAntibodyIntensive care medicineDiseaseCancerSystemic Lupus Erythematosus ResearchCytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology