Rh(<scp>iii</scp>)-catalyzed redox-neutral C–H [4 + 1] annulation of sulfoximines with α,α-difluoromethylene alkynes: diastereoselective synthesis of <i>E</i>-monofluoroalkenyl benzoisothiazole 1-oxides
Ting Wang, Zhi‐Huan Peng, Liexin Wu, Qingwei Song, Qianying Li, Hui Gao, Zhongyi Zeng, Zhi Zhou, Wei Yi
Abstract
Rh( iii )-catalyzed redox-neutral C–H [4 + 1] annulation of sulfoximines with α,α-difluoromethylene alkynes has been realized to diastereoselectively build E -monofluoroalkenyl benzoisothiazole 1-oxides.
Topics & Concepts
ChemistryAnnulationRedoxCatalysisMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions