Lipid in microglial biology — from material to mediator
Shota Yamamoto, Takahiro Masuda
Abstract
Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.
Topics & Concepts
MicrogliaLipid metabolismBiologyNeuroscienceReprogrammingLipid signalingCentral nervous systemMechanism (biology)MediatorPathogenesisCellCell biologyCrosstalkInflammationImmunologyGeneticsBiochemistryPhilosophyEpistemologyOpticsPhysicsNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerPeroxisome Proliferator-Activated Receptors