Rational design synthesis and evaluation of a novel near-infrared fluorescent probe for selective imaging of amyloid-β aggregates in Alzheimer's disease
Bingxin Wang, Jun-Zhuo Shi, Ning Guo, Lulian Shao, Weibin Zhai, Lei Jiang, Fenqin Zhao, Jianhong Wang, Junfeng Wang, Li-Da Du, Xiaobin Pang, Lin Yan
Topics & Concepts
ChemistryThioflavinFluorescenceStokes shiftIn vivoAmyloid (mycology)In vitroRational designGenetically modified mouseBiophysicsTransgeneAlzheimer's diseasePathologyBiochemistryDiseaseNanotechnologyOpticsMedicineBiotechnologyGeneBiologyInorganic chemistryMaterials sciencePhysicsAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesTryptophan and brain disorders