Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus
Yuko Sato, Tadahiro Suenaga, Makoto Kobayashi, Nozomu Miyazaki, Takato Suzuki, Ken Ishioka, Tatsuo Suzutani
Abstract
as the parent HSV-1, although other mutants showed attenuated virulence. All recombinant viruses were susceptible to the other antiherpetic drugs, acyclovir and foscarnet. In conclusion, based on BAC mutagenesis, this study identified, for the first time, mutations in UL5 and UL52 that contributed to AMNV resistance and found that a mutant with the most frequent K356N mutation in HSV-1 maintained viral growth and virulence equivalent to the parent virus.
Topics & Concepts
VirologyPrimaseHerpes simplex virusBiologyViral replicationMutagenesisVirusResistance mutationMutantMolecular biologyGeneticsGenePolymerase chain reactionReverse transcriptaseHerpesvirus Infections and TreatmentsPoxvirus research and outbreaksVirus-based gene therapy research