Catalytic olefin metathesis in blood
Igor Nasibullin, H. YOSHIOKA, Akari Mukaimine, Akiko Nakamura, Yuriko Kusakari, Tsung‐Che Chang, Katsunori Tanaka
Abstract
A Ru-based artificial metalloenzyme (ArM) at just 1–5 mol% could catalyze olefin metathesis in blood to construct various molecular scaffolds. The cancer-targeting ArM at a low dosage could elicit tumor growth inhibition by in vivo drug synthesis.
Topics & Concepts
In vivoChemistryDrugOlefin fiberCatalysisCombinatorial chemistryOlefin metathesisReactivity (psychology)In vitroMetathesisPharmacologyBiochemistryMedicineOrganic chemistryBiologyPolymerizationAlternative medicinePathologyBiotechnologyPolymerSynthetic Organic Chemistry MethodsChemical Synthesis and AnalysisPeptidase Inhibition and Analysis