Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome
Yu-Han H. Hsu, Christina M. Astley, Joanne B. Cole, Sailaja Vedantam, Josep M. Mercader, Andres Metspalu, Krista Fischer, Kristen Fortney, Eric Morgen, Clicerio González, Maria E. González, Tõnu Esko, Joel N. Hirschhorn
Topics & Concepts
Mendelian randomizationMetabolomicsMetaboliteMetabolomeCausal inferenceComputational biologyBiologyBioinformaticsGeneticsMedicineGenotypeGeneBiochemistryGenetic variantsPathologyMetabolomics and Mass Spectrometry StudiesGenetic Associations and EpidemiologyNutrition, Genetics, and Disease