Modified pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation
Eman S. Nossier, Rania A. Alasfoury, Mohamed Hagras, May A. El‐Manawaty, Sara M. Sayed, Ibrahim M. Ibrahim, Hazem Elkady, Ibrahim H. Eissa, Heba S. A. Elzahabi
Topics & Concepts
ChemistryErlotinibIC50StereochemistryDocking (animal)MutantCell cultureKinaseInhibitory postsynaptic potentialApoptosisPharmacologyCell cycle checkpointLead compoundCombinatorial chemistryCell cycleIn vitroBiochemistryEpidermal growth factor receptorReceptorGeneBiologyNursingMedicineGeneticsNeuroscienceQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsSynthesis and biological activity